In the present research, we want to study synthesis of some isotopes of Flerovium ، ، and were produced in the nuclear fusion of 48Ca ions with 239Pu, 240Pu, 241Pu, and 242Pu nuclei. We obtain the parameters of the fusion barriers between48Ca ions with Pu isotopes and compare these parameters with each other. Furthermore, we investigate influence of the direction of target nuclei on the parameters of the fusion barriers. we show that the minimum energies for synthesis of 287Fl, 288Fl, 289Fl and 290Fl nuclei are 184.16 MeV, 183.95 MeV, 183.75 MeV and 183.56 MeV. Finally in the framework of the statistical model, we estimate the evaporation residue cross section for 286Fl, 287Fl nuclei after emission of three and four neutrons from 290Fl nuclei and we will show that the results of calculations for 286Fl nuclei are in good agreement with the experimental data. Although, the results of the calculations of the evaporation residue cross section for 287Fl nuclei lie somewhat below the results of the experimental data.