Authors
Abstract
Calcium channels are cell membrane proteins that play an important role in control the Ca ion flux through the membrane. In this study, the effect of external constant electric field on the dynamics of calcium ions in a L-type channel, located within a stochastically fluctuating medium, is modeled via the application of the molecular dynamics (MD) simulation method. The obtained results show that application of constant field of 0.03 V/nm did not show significant effect on the ions motion. On the other hand, when the channel is exposed to a constant electric field of strength 0.3 V/nm, the ions directional motion along the applied field is observed. Furthermore, it is found that no net motion is observed when the field direction is changed.
Keywords
2. C Suwattanasophon, “Molecular Modeling of Voltage-gated Calcium channels”, Uniwien (2012).
3. G W Zamponi, “Voltage-gated calcium channels”, Springer (2005).
4. G Fernández-Ballester, A Fernández-Carvajal, J M González-Ros, and A Ferrer-Montiel, Pharmaceutics 3 (2011) 932.
5. D Gillespie, Biophysical journal 94 (2008) 1169.
6. T D Helton, W Xu, and D Lipscombe, The Journal of neuroscience 25 (2005) 10247.
7. L Almagor, O Chomsky-Hecht, A Ben-Mocha, D Hendin-Barak, N Dascal, and J A Hirsch, The Journal of Neuroscience 32 (2012) 7602.
8. L Tang, T M G El-Din, J Payandeh, G Q Martinez, T M Heard, T Scheuer, N Zheng, and W A Catterall, Nature 505 (2014) 56.
9. I Bidaud, A Mezghrani, L A Swayne, A Monteil, and P Lory, Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1763 (2006) 1169.
10. W A Catterall, Cold Spring Harbor perspectives in biology 3 (2011) a003947.
11. E Perez-Reyes, Physiological Reviews 83 (2003) 117.
12. D Lipscombe, Circulation research 90 (2002) 933.
13. A Davies, I Kadurin, A Alvarez-Laviada, L Douglas, M Nieto-Rostro, C S Bauer, W S Pratt, and A C Dolphin, Proceedings of the National Academy of Sciences 107 (2010) 1654.
14. F Findeisen, and J Minor, and Daniel L, Channels 4 (2010) 459.
15. A Malasics, D Gillespie, W Nonner, D Henderson, B Eisenberg, and D Boda, Biochimica et Biophysica Acta (BBA)-Biomembranes 1788 (2009) 2471.
16. B Corry, T W Allen, S Kuyucak, and S H Chung, Biophysical Journal 80 (2001) 195.
17. H K Motoike, I Bodi, H Nakayama, A Schwartz, and G Varadi, Journal of Biological Chemistry 274 (1999) 9409.
18. R C Cheng, D B Tikhonov, and B S Zhorov, Journal of Biological Chemistry 284 (2009) 28332.
19. M Sajadi, A Lohrasebi, and H Rafii-Tabar, Journal of Molecular Simulation 405 (2014) 399.
20. F Khalili-Araghi, E Tajkhorshid, and K Schulten, Biophysical Journal 91 (2006) L72.
21. Y Zhao, J Xu, J Bo Gong, and L Qian, Cell stress society international 14 (2008)
22. R Mukherjee, k w Hewett, J D Walker, C G Basler, and F G Spinale, Cardiovascular Research 37 (1998) 432.
23. A Caflisch and M Karplus, Proceedings of the National Academy of Sciences 91 (1994) 1746.
)