Iranian Journal of Physics Research

Simulations of DNA damage types and frequencies induced by carbon ions

Document Type : Original Article

Authors

Hossein Moeini 1
Mojtaba Mokari 2

1 Department of Physics, School of Science, Shiraz University, Shiraz, Iran

2 Department of Physics, Behbahan Khatam Alanbia University of Technology, Behbahan, Iran

https://doi.org/10.47176/ijpr.23.2.31666
Abstract
Carbon ions’ dose distribution, in comparison with lighter hadrons, has certain therapeutic advantages due to their relatively higher biological effectiveness in tumors. Simulating the physical and chemical interactions of carbon ions in a sphere of liquid water of cellular scales, we derived the mean number of deposited energies per unit dose per a DNA segment of 216 bp as a function of deposited energy. As such, the frequency of complex damage was obtained from the point of view of a multiplicity of damage points on the DNA strands. Furthermore, the damage yields for different types of single- and double-strand breaks were obtained and, specifically, the mean number of simple single- and double-strand breaks per DNA segment were calculated as a function of deposited energy

Keywords

damage yield
DNA damage
Geant4-DNA code
carbon ion
µ-randomness method
Subjects
  1. T Friedrich, U Scholz, T Elsasser, M Durante, and M Scholz, Radiat. Res. 54 (2013) 494.
  2. W Friedland, E Schmitt, P Kundrat, M Dingfelder, G Baiocco, S Barbieri, and A Ottolenghi, Rep. 7 (2017) 45161.
  3. S J McMahon, A L McNamara, J Schuemann, H Paganetti, and K M Prise, Rep. 7 (2017) 10790.
  4. S Incerti, I Kyriakou, M Bernal, M Bordages, Z Francis, S Guatelli, et al., Phys. 45 (2018) 722.
  5. S Incerti, A Ivanchenko, M Karamitros, A Mantero, P Moretto, H N Tran, et al., Phys. 37 (2010) 4692.
  6. S Meylan, S Incerti, M Karamitros, N Tang, M Bueno, I Clairand, and C Villagrasa, Rep. 7 (2017) 11923.
  7. N Lampe, M Karamitros, V Breton, et al., Physica Medica 48 (2018) 146.
  8. M Mokari, M H Alamatsaz, H Moeini, and R Taleei, Physics in Medicine & Biology 63 (2018) 175003.
  9. M Mokari, H Moeini, and M H Alamatsaz, Iranian Journal of Physics Research 16 (2019) 621 (Persian).
  10. M Mokari, H Moeini, and M Eghbali, Iranian Journal of Radiation Safety and Measurement 23 (2020) 65 (Persian).
  11. H Moeini, M Mokari, M H Alamatsaz, and R Taleei, International Journal of Radiation Biology 96 (2020) 767.
  12. H Moeini, and M Mokari, “Simulation of primary DNA damage by alpha particles compared to protons and electrons”, The Annual Nuclear Conference of Iran (2020) (Persian).
  13. R Taleei, Protection Dosimetry 183 (2019) 75.
  14. Z Ahmadi-Ganjeh, M Eslami-Kalantari, M Ebrahimi-Loushab, and A Asghar-Mowlavi, Radiation Physics and Chemistry 179 (2021) 109249.
  15. D J Buglewicz, K D Walsh, H Hirakawa, et al., Frontiers in Oncology 17 (2022) 788293.
  16. ICRU, “Key Data for Ionizing-Radiation Dosimetry: Measurement Standards and Applications”, Bethesda, MD, USA: (The International Commission on Radiation Units and Measurements) 2014.
  17. L De la Fuente Rosales, S Incerti, Z Francisc, M A Bernal, Med. 51 (2018) 108.
  18. A M Kellerer, “Fandamental of microdosimetry, in The Dosimetry of Ionizing Radiation”, vol. 1, K R Kase, B E Bjarngaard, F H Attix, Eds., (Academic Press) 1975.
  19. R F Martin and W A Haseltine, Science 213 (1981) 896.
  20. S Kandaiya, P N Lobachevsky, G D'cunha, and R F Martin, Acta Oncologica 35 (1996) 803.

Home

Guide for Authors

Submit Manuscript

Reviewers

Contact Us

تحت نظارت وف بومی