نوع مقاله : مقاله مروری

نویسندگان

دانشکده فیزیک، دانشگاه تبریز، تبریز

چکیده

نانوذرات فریت‌های ‏ اسپینلی از مهم‌ترین مواد مغناطیسی به شمار‌‌ می‌آیند که در دو دهة اخیر استفاده از آنها در حوزه‌های مختلف به طرز چشمگیری در حال افزایش است. با معرفی و ورود این نانومواد به حوزة پزشکی و مطرح شدن ایدۀ استفاده از آنها در کاربردهای مختلف درمانی و بالینی، محققان زیادی در این زمینه شروع به پژوهش کرده و یافته‌های جدیدی را ارائه کرده‌اند. از جمله مهم‌ترین کاربردها و ایده‌های استفاده از نانوذرات فریت‌های ‏ اسپینلی در حوزة پزشکی‌‌ می‌توان به افزایش وضوح تصاویر در تصویربرداری تشدید مغناطیسی اشاره کرد. نتایج تحقیقات تجربی روی موجودات زنده نشان‌‌ می‌دهد که وارد کردن نانوذرات فریت‌های ‏ اسپینلی در نزدیکی غدد سرطانی باعث افزایش وضوح تصاویر‌‌ می‌شود و تشخیص بیماری‌ها را آسان‌تر می‌کند. گرمادرمانی مغناطیسی یکی دیگر از کاربردهای نانوذرات فریت‌های ‏ اسپینلی است که در آن عوامل متعددی روی بازده فرایند تاثیر گذار است. این روش هنوز به صورت کاربردی روی انسان گسترش پیدا نکرده و بیشتر به صورت تحقیقاتی و آزمایشگاهی در حال مطالعه‌‌ است. دارورسانی هدفمند، سومین کاربرد نانوذرات فریت‌های ‏ اسپینلی در حوزة پزشکی‌‌ ‌‌ است و یکی از پیشرفته‌ترین روش‌های درمانی به شمار می‌آید. جهت حصول بهترین نتیجه، پارامترهای متعددی در این روش باید در نظر گرفته شود. با توجه به اهمیت موضوع سلامتی و درمان بیماری‌های صعب العلاج، هدف اصلی این مقاله مروری بر فعالیت‌های انجام یافته در استفاده از نانوذرات فریت‌های ‏ اسپینلی در این سه روش‌ است.

کلیدواژه‌ها

عنوان مقاله [English]

Advanced applications of spinel ferrite nanoparticles in medicine: Magnetic hyperthermia, magnetic resonance imaging and targeted ‎drug delivery

نویسندگان [English]

  • H Jalili
  • B Aslibeiki
  • N Eskandarzadeh

Faculty of Physics, University of Tabriz, Tabriz, Iran

چکیده [English]

Spinel ferrites nanoparticles are among the most important magnetic materials and their applications in ‎different areas have increased significantly in the last two decades. The idea of using ferrites ‎nanoparticles in medical applications, caused attraction of attention of researchers in worldwide to this field ‎and increase number of studies on the subject. The increase of the magnetic resonance imaging (MRI) contrast is one ‎of the most important medical applications of spinel ferrite nanoparticles. The imaging results of ‎live organisms show that the spinel ferrite nanoparticles can increase the contrast of images of ‎cancerous cells and therefore help tumors diagnosis. Magnetic hyperthermia is another ‎application of spinel ferrite nanoparticles, in which several factors affect the specific adsorption ‎rate and efficiency of the method. However, this method has not yet been applied to human kind, ‎and it is being studied in laboratories on animals like mouse etc. Targeted drug delivery is the ‎third application of spinel ferrite nanoparticles in the field of medicine. This method is one of the ‎most advanced treatment routes. In this method, several parameters must be considered to ‎achieve the best results. Considering the importance of health and treatment, the main purpose of ‎this review is to give the latest results of studies on the three mentioned methods on using the ‎spinel ferrite nanoparticles for medical purposes‎.

کلیدواژه‌ها [English]

  • magnetic nanoparticles
  • spinel ferrites
  • medical applications
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